Antifungal susceptibility testing of Candida isolates from PLHIV patients

Introduction- There is a growing prevalence of fungal infections among immunocompromised patients, and there also concerning rise in resistance to commonly used antifungal medications. As result, drug susceptibility testing has become an invaluable tool for clinicians, specifically the treatment invasive cases where initial treatments have proven ineffective. Methodology- We conducted analysis patterns 62 Candida isolates derived from various infection sites cohort 165 PLHIV patients using broth macrodilution method. Results- A high was observed azole group with highest being Fluconazole (27%) followed by Voriconazole (14.5%) Itraconazole (12.9%). No recorded Amphotericin B Caspofungin. Discussion- Our findings indicate higher Fluconazole, non-albicans (NAC) species compared albicans. The presence cross-resistance between voriconazole matter concern. However, it important note that no instances were both Nevertheless, elevated minimum inhibitory concentrations (MICs) noted these agents. Conclusion- Routinely performing laboratories crucial due antifungals, especially group. This led emergence highly resistant more harmful species. Thanks availability standardised automated manual methods, conducting such tests accessible. Therefore, we strongly recommend routine ensure appropriate decisions patients.